No, MTHFR isn’t short form for you know what – even though it really can be one! We all have the MTHFR gene, but some of us have genetic variations or mutations. I recently found out I am one of the few who do have a mutation. But it’s not all bad! Your genes are not your fate, thanks to gene expression and epigenetics. In this episode, I talk about what the MTHFR gene is involved in and what having a mutation means. It’s involved in SO MANY body processes! For example, hormonal balance, birth defects, anxiety, depression, weight gain, cardiovascular disease, the list goes on. I’m glad I found out about this genetic variation so that I can do something about it. Be proactive with your health! If you’ve already done some sort of gene testing through 23andMe or Ancestry DNA then you’re one step ahead.
YOUR GENETICS ARE NOT YOUR FATE.
SNPs to check for:
Results for rs1801133
- AA 2 copies of variant allele, MTHFR activity reduced by 70-80%
- AG 1 copy of variant allele, MTHFR activity reduced by about 40%
- GG both normal alleles, normal activity
Results for rs1801131
- GG 2 copies of the variant allele, MTHFR activity reduced slightly
- GT 1 copy of variant allele, MTHFR activity reduced slightly
- TT both normal alleles, normal activity
Resources:
What are MTHFR Genes/Polymorphisms (C677T, Rs1801133)?
Prothrombotic Conditions, Oral Contraceptives, and the Risk of Ischemic Stroke
- Women who take oral contraceptives that have rs1801133 double mutation AA (also called MTHFR 677TT) have an increased risk of stroke than women who do not have the mutation
